Retinoblastoma is an eye cancer that primarily affects children. It is a rare form of cancer, occurring in only one out of every 18,000 to 30,000 live births. Unfortunately, it is very aggressive and can result in blindness or even death if left untreated. While the exact cause of retinoblastoma remains unknown, researchers have identified several factors that may increase a child’s risk of developing the disease.
Genetic Factors
Hereditary retinoblastoma is caused by a gene mutation that is passed from parent to child. This type of retinoblastoma accounts for approximately 40% of all cases. The mutated gene is usually located on the long arm of chromosome 13 and is called the retinoblastoma gene.
It is believed that a child inherits two copies of this gene, one from each parent. If a child inherits a mutated copy of the gene from one of the parents, the child will be at a much higher risk of developing retinoblastoma.
Environmental Factors
While genetic factors are the primary cause of retinoblastoma, some environmental factors may also play a role. For example, some studies have suggested that exposure to certain chemicals, such as benzene, may increase a child’s risk of developing the disease.
Radiation exposure, such as x-rays or radiation therapy, may also increase a child’s risk of developing retinoblastoma. Additionally, some evidence suggests that mothers who smoked during pregnancy may be more likely to have a child with retinoblastoma.
Conclusion
Retinoblastoma is a rare form of cancer that primarily affects children. While the exact cause of retinoblastoma remains unknown, researchers believe that both genetic and environmental factors may play a role in its development. Genetic mutations in the retinoblastoma gene, exposure to certain chemicals, and radiation exposure may all increase a child’s risk of developing the disease.