Introduction
Addison disease is a rare chronic disorder caused by the destruction of the outer layer of the adrenal glands (the cortex). This disorder is characterized by a deficiency in the production of glucocorticoid and mineralocorticoid hormones. As a result, individuals with Addison disease may experience a variety of symptoms, including fatigue, weight loss, low blood pressure, and darkening of the skin.
Which Hormone is Excess in Addison Disease?
The primary hormone that is excess in Addison disease is the hormone cortisol. Cortisol is a glucocorticoid hormone that is secreted by the adrenal glands in response to stress. It helps regulate blood pressure, sugar levels, and the body’s response to inflammation. In individuals with Addison disease, the adrenal glands are unable to produce enough cortisol, causing levels of the hormone to become excessively high.
Symptoms of Excess Cortisol
Excess cortisol can cause a variety of symptoms, including fatigue, weight gain, high blood pressure, and an increased heart rate. Additionally, individuals with Addison disease may experience mood changes and depression. Other symptoms of excess cortisol include thinning of the skin, menstrual irregularities, and difficulty sleeping.
Treatment for Excess Cortisol in Addison Disease
The primary treatment for excess cortisol in Addison disease is replacement therapy. This involves taking daily doses of glucocorticoid medications to replace the hormones that the body is unable to produce. Additionally, individuals with Addison disease may need to take mineralocorticoid medications to replace the hormones that are missing from the adrenal glands.
Conclusion
Excess cortisol is a common symptom of Addison disease. It can cause a variety of symptoms, including fatigue, weight gain, high blood pressure, and an increased heart rate. Treatment for excess cortisol in Addison disease typically involves taking daily doses of glucocorticoid and mineralocorticoid medications.