Ankylosing spondylitis is a type of inflammatory arthritis that primarily affects the spine and sacroiliac joints. It can cause pain, stiffness, and reduced mobility in the spine and other joints. It can also lead to fusion of the spine and other joints, making movement difficult. The exact cause of ankylosing spondylitis is unknown, but it is believed to be due to a combination of genetic and environmental factors.
What Causes Ankylosing Spondylitis?
The exact cause of ankylosing spondylitis is unknown, but it is believed to be due to a combination of genetic and environmental factors. Genetic factors may play a role in the development of ankylosing spondylitis, as the disease tends to run in families. There are certain genetic markers associated with ankylosing spondylitis, including mutations in the HLA-B27 gene. This gene is found in about 8 out of 10 people with ankylosing spondylitis.
Environmental factors, such as certain bacterial or viral infections, may also play a role in the development of ankylosing spondylitis.
When Does Ankylosing Spondylitis Start?
Ankylosing spondylitis typically starts in early adulthood, with symptoms usually beginning between the ages of 17 and 35. The condition can affect adults of any age, however, and can even develop in children. Symptoms may start gradually, with mild stiffness and pain in the lower back and hips. As the condition progresses, the pain and stiffness may become more severe and may spread to other areas of the spine and body, such as the shoulders, neck, and ribs.