What Is IgG4?
IgG4 is a type of immunoglobulin, which is a protein produced by the body's immune system to help protect it from infection and disease. IgG4 antibodies are found in the blood, and their levels can be measured through a blood test. The normal IgG4 range is usually between 0.5 and 1.5 g/L, but this can vary depending on the laboratory.
What Is the Role of IgG4?
IgG4 helps the body to recognize and fight off foreign substances, such as bacteria and viruses. It also helps to regulate inflammation, which is the body's natural response to infection or injury. It also helps to protect the body from autoimmune diseases, which are conditions in which the body's own immune system mistakenly attacks healthy cells and tissues.
What Causes High or Low IgG4 Levels?
High levels of IgG4 can be caused by certain infections, such as tuberculosis and HIV. It can also be caused by autoimmune diseases, such as lupus and rheumatoid arthritis. Low levels of IgG4 can be caused by a deficiency in the body's ability to produce immunoglobulins, or by certain treatments, such as chemotherapy.
What Are the Symptoms of High or Low IgG4 Levels?
High levels of IgG4 can cause fever, fatigue, and swollen lymph nodes. Low levels of IgG4 can cause frequent infections and a weakened immune system.
What Are the Treatment Options for High or Low IgG4 Levels?
Treatment for high IgG4 levels depends on the underlying cause. Treatment may include antibiotics, steroids, or immunosuppressants. Treatment for low IgG4 levels may include vitamin and mineral supplements, as well as immunoglobulin replacement therapy or other treatments to boost the immune system.