The first-line antifungal drug for Aspergillus is an azole. Azoles are a class of antifungals used to treat fungal infections. Examples of azoles used to treat Aspergillus include voriconazole, itraconazole, and posaconazole.
Voriconazole is usually the first-line treatment for Aspergillus, as it has the highest response rate and is the most cost-effective option. Voriconazole is usually given orally in a dosage of 200-400mg twice daily for the first week, followed by 200-400mg once daily in the following weeks.
Itraconazole is another antifungal that is used to treat Aspergillus. It is usually given orally in a dosage of 200-400mg once daily for two to three months. It is less expensive than voriconazole, but also has a lower response rate.
Posaconazole is the third azole antifungal used to treat Aspergillus. It is usually given as an intravenous infusion in a dosage of 400-800mg once daily for two to three months. It has the highest response rate, but is also the most expensive option.
In summary, the first-line antifungal for Aspergillus is an azole, typically voriconazole. If voriconazole is not an option, itraconazole or posaconazole can be used as an alternative.