Autoimmune hepatitis (AIH) is a chronic liver disease in which the body's immune system attacks and damages liver cells. It is a complex condition and the exact cause is unknown. However, certain drugs have been linked to the development of AIH in some people.
Drugs That May Trigger Autoimmune Hepatitis
The most common drugs associated with the onset of AIH are NSAIDs (nonsteroidal anti-inflammatory drugs), such as ibuprofen and naproxen, and antibiotics, such as minocycline and nitrofurantoin. Other drugs, such as oral contraceptives, interferon alfa, and certain antiepileptic medications, have also been reported to cause AIH.
Signs and Symptoms of Autoimmune Hepatitis
The signs and symptoms of AIH vary from person to person, but commonly include fatigue, abdominal pain, jaundice (yellowing of the skin and eyes), dark urine, and itching. In some cases, AIH can lead to cirrhosis (scarring of the liver) and liver failure.
Diagnosis and Treatment of Autoimmune Hepatitis
AIH is typically diagnosed using a combination of blood tests, imaging studies, and a liver biopsy. Treatment usually involves a combination of medications to suppress the immune system and reduce inflammation. In some cases, a liver transplant may be necessary.
Preventing Autoimmune Hepatitis
The best way to prevent AIH is to avoid taking any medications that have been linked to the onset of AIH. It is also important to talk to your doctor about any potential side effects of any medications you may be taking.