Total IgE (Immunoglobulin E) is an antibody produced by the body in response to allergens and other foreign substances. It is a marker of atopy, which is the tendency to develop allergies. A high level of IgE in the blood indicates a heightened sensitivity to allergens and other environmental factors.
What Causes High Total IgE Levels?
High levels of Total IgE can be caused by a variety of factors, including genetics, environmental exposures, chronic infections, and certain medications. Allergens, such as pollen, molds, and dust mites, can also trigger an increase in IgE levels. In some cases, a high Total IgE level is a sign of an underlying medical condition, such as asthma, eczema, or hay fever.
What Are the Symptoms of High Total IgE?
The symptoms of high Total IgE levels vary depending on the underlying cause. Common symptoms include nasal congestion, sneezing, itchy eyes, and skin rashes. If the high IgE is caused by an allergic reaction, the person may also experience hives, wheezing, and difficulty breathing. In severe cases, anaphylaxis may occur.
How Is High Total IgE Diagnosed?
High levels of IgE can be diagnosed through a blood test. The doctor will look for elevated levels of IgE and other markers, such as eosinophils, to confirm a diagnosis. If the IgE levels are higher than normal, the doctor may recommend additional tests or a skin prick test to determine the cause of the elevated IgE.
How Is High Total IgE Treated?
Treatment for high Total IgE depends on the underlying cause. If the cause is an allergy, the doctor may prescribe antihistamines or other medications to reduce the IgE levels and manage symptoms. If the cause is a chronic infection or an underlying medical condition, the doctor will treat the underlying condition. In some cases, immunotherapy may be recommended to reduce IgE levels and reduce the risk of future allergic reactions.