An anti-nuclear antibody (ANA) is a type of antibody produced by the body's immune system that is directed against one or more of the body's own proteins, which are found in the nucleus of cells, the center of the cell. ANAs are typically found in the blood and can be used to detect autoimmune diseases.
In people with autoimmune diseases, the body's immune system produces antibodies that mistakenly attack its own tissues and organs. In the case of an ANA test, the antibodies are directed against proteins that are found in the nucleus of cells, which is the center of the cell. ANA testing is used to detect the presence of these autoantibodies in the blood, which can indicate the presence of an autoimmune disorder.
The ANA test is typically performed as part of a comprehensive autoimmune workup. It is most commonly used to help diagnose conditions such as systemic lupus erythematosus (SLE), Sjogren's syndrome, polymyositis, and scleroderma. It can also be used to help diagnose other conditions such as rheumatoid arthritis, Sjogren’s syndrome, and SLE.
ANA testing involves taking a sample of blood and sending it to a lab for analysis. The lab will analyze the sample for the presence of ANA antibodies. If the test is positive, it means that autoantibodies are present in the sample, which could indicate the presence of an autoimmune disorder. If the test is negative, it means that no autoantibodies were detected, which could mean that there is no autoimmune disorder present.
The ANA test is not foolproof, however, as a positive result does not always mean that an autoimmune disorder is present. Additionally, a negative result does not always mean that an autoimmune disorder is not present. Therefore, it is important to discuss the results of the ANA test with your doctor to determine the best course of action.