Clostridium difficile (C. difficile) is a bacterium that can cause a range of gastrointestinal conditions, including diarrhea. C. difficile infection (CDI) is one of the most common causes of healthcare-associated diarrhea, particularly in hospital settings, and can be associated with significant morbidity and mortality.
Risk Factors
There are a number of risk factors for CDI, including antibiotic use, advanced age, prolonged hospitalization, presence of a central venous catheter, use of proton pump inhibitors, and underlying gastrointestinal disorders. Patients may also be at increased risk for CDI if they are immunocompromised or have a weakened immune system.
Transmission
C. difficile is typically spread through contact with contaminated surfaces or ingestion of contaminated food or water. It can also be spread through direct contact with an infected person, such as through close contact with a healthcare worker or sharing a bed with an infected person.
Symptoms
The most common symptoms of CDI are watery diarrhea, abdominal pain, and fever. Other symptoms may include nausea, vomiting, loss of appetite, and weight loss. In severe cases, C. difficile can lead to dehydration, electrolyte imbalance, and even death.
Diagnosis
CDI is usually diagnosed through testing of a stool sample. The sample is examined for the presence of C. difficile toxins. Other tests, such as blood tests, may also be used to confirm the diagnosis.
Treatment
Treatment for CDI typically involves the use of antibiotics. Antibiotic therapy is usually successful in treating mild to moderate cases of CDI. However, in severe cases, additional treatments, such as fecal microbiota transplantation, may be necessary.