Autoimmune Polyglandular Syndrome Type 3 (APS-3) is a rare autoimmune disorder in which the body’s immune system mistakenly attacks and destroys healthy tissue and cells. It is characterized by the presence of multiple autoimmune disorders, including Addison’s disease, which affects the adrenal glands, and hypoparathyroidism, which affects the parathyroid glands.
Common symptoms of APS-3 include fatigue, muscle weakness, abdominal pain, nausea, vomiting, weight loss, decreased appetite, joint pain, difficulty concentrating, and mood swings. Patients may also experience tingling or numbness in the hands or feet, difficulty breathing, and vision changes. Additionally, some people with APS-3 may experience an increase in infections due to a weakened immune system.
Other signs and symptoms associated with APS-3 include low blood pressure, increased heart rate, and electrolyte imbalances. Patients may also have a low sodium level, high potassium level, and low calcium level. Endocrinological tests can confirm the presence of APS-3 and provide information about the underlying cause.
In some cases, patients with APS-3 may also experience neurological symptoms such as confusion, depression, and difficulty with memory and concentration. Patients may also have difficulty with coordination and balance.
Treatment for APS-3 typically includes hormone replacement therapy and medications to suppress the immune system. In some cases, surgery may be necessary to replace or remove damaged organs. The prognosis of APS-3 depends on the underlying cause and the severity of the symptoms. With proper diagnosis and treatment, patients can often lead a normal life.