Adrenal insufficiency, or Addison's disease, is a disorder that occurs when the adrenal glands do not produce enough of the hormones cortisol and/or aldosterone. Lab findings for adrenal insufficiency can vary depending on the severity of the condition.
The most common lab findings for adrenal insufficiency include an elevated level of serum potassium, a decreased level of serum sodium, a decreased level of serum chloride, a decreased level of serum bicarbonate, an elevated level of serum creatinine, an elevated level of serum urea nitrogen, an elevated level of serum uric acid, and a decreased level of serum cortisol. Other lab findings can include an elevated level of serum prolactin, a decreased level of serum growth hormone, and an elevated level of serum adrenocorticotropic hormone (ACTH).
In addition, an MRI or CT scan of the adrenal glands may be performed to look for any structural abnormalities. Blood tests may also be done to measure the levels of hormones such as testosterone, dehydroepiandrosterone sulfate (DHEA-S), and cortisol.
If a person is suspected of having adrenal insufficiency, a doctor may order an ACTH stimulation test. This test measures the response of the adrenal glands to an injection of ACTH. If a person has adrenal insufficiency, their cortisol levels will remain low regardless of the amount of ACTH injected.
Overall, the lab findings for adrenal insufficiency can vary depending on the severity of the condition, but typically involve an elevated level of serum potassium, a decreased level of serum sodium, a decreased level of serum chloride, a decreased level of serum bicarbonate, an elevated level of serum creatinine, an elevated level of serum urea nitrogen, an elevated level of serum uric acid, a decreased level of serum cortisol, an elevated level of serum prolactin, a decreased level of serum growth hormone, and an elevated level of serum adrenocorticotropic hormone (ACTH).