Aplastic Anemia in Adults
Aplastic anemia is a rare but serious medical condition in which the body is unable to produce enough new blood cells. It is a type of bone marrow failure, which occurs when the bone marrow does not produce enough red blood cells, white blood cells, and platelets. This can lead to anemia, an increased risk of infection, and easy bruising or bleeding.
Although aplastic anemia can affect people of all ages, it is most commonly seen in adults. It is estimated that aplastic anemia affects between 1 in 500,000 to 1 in 1 million adults in the United States. This condition is thought to be caused by a disruption in the bone marrow’s stem cells, which are responsible for the production of new blood cells.
Risk Factors
Aplastic anemia is thought to be caused by a variety of factors, including:
-Exposure to toxic chemicals, such as benzene, insecticides, or solvents
-Exposure to radiation
-Certain viral infections, such as hepatitis or HIV/AIDS
-Certain medications, such as antibiotics or chemotherapy
-Autoimmune disorders, such as lupus or rheumatoid arthritis
-Genetic disorders, such as Fanconi anemia or Diamond-Blackfan anemia
Symptoms
The most common symptom of aplastic anemia is fatigue, which is caused by the body not having enough red blood cells to carry oxygen to the body’s tissues and organs. Other symptoms may include:
-Shortness of breath
-Dizziness
-Pale skin
-Easy bruising or bleeding
-Frequent or severe infections
-Rapid heart rate
-Enlarged spleen or liver
Diagnosis
Aplastic anemia is usually diagnosed by a combination of blood tests, bone marrow tests, and physical exams. A complete blood count (CBC) can help to determine if a person has aplastic anemia by measuring the levels of red blood cells, white blood cells, and platelets. A bone marrow biopsy can help to confirm the diagnosis and determine the severity of the condition.
Treatment
Treatment for aplastic anemia depends on the severity of the condition. Mild cases may not require treatment, but severe cases may require medication, blood transfusions, or a bone marrow transplant.
Medication: Medications such as antithymocyte globulin or cyclosporine can help to suppress the immune system and encourage the bone marrow to produce new blood cells.
Blood Transfusions: Blood transfusions can be used to increase the number of red blood cells in the body.
Bone Marrow Transplant: A bone marrow transplant is a last resort option for people with severe cases of aplastic anemia. This procedure involves replacing the bone marrow with healthy marrow from a donor.
Prevention
There is no way to prevent aplastic anemia, but some steps can be taken to reduce the risk of developing the condition. These include avoiding exposure to toxic chemicals, radiation, and certain medications, and getting vaccinated against viral infections like hepatitis and HIV/AIDS.