Paget disease is a serious condition that affects the bones of the body. It is caused by a defect in the metabolism of bone and is characterized by an accelerated rate of bone turnover, resulting in weakened and deformed bones. It can affect any bone in the body, but is most commonly seen in the pelvis, spine, skull, and long bones of the arms and legs.
The most common symptom of Paget disease is bone pain. Other symptoms can include deformity of the affected area, joint swelling and stiffness, and increased risk of fractures. In severe cases, Paget disease can lead to neurological problems, such as hearing loss, tinnitus, and balance problems. It can also lead to an increased risk of certain types of cancers, such as osteosarcoma and chondrosarcoma.
In most cases, Paget disease can be managed with medication and lifestyle changes. For example, exercise can help to reduce bone pain and improve muscle strength. In severe cases, surgery may be required to correct the deformity and reduce the risk of fractures.
Overall, Paget disease is a serious condition that can have a significant impact on an individual's quality of life. Treatment is necessary to manage the symptoms and reduce the risk of complications. If left untreated, Paget disease can lead to serious complications, such as fractures, neurological problems, and an increased risk of certain types of cancers.