Haemolytic disease of the newborn (HDN) is a condition that affects newborn babies and is caused by the mother's immune system attacking the baby’s red blood cells. It is also known as erythroblastosis fetalis or Rh disease. HDN is relatively uncommon, but can be serious if it is not treated properly.
What Causes HDN?
HDN is caused by a difference in the mother and baby’s blood types. It can occur when the mother’s blood type (Rh-negative) is incompatible with the baby’s (Rh-positive). This difference can cause the mother’s body to develop antibodies against the baby’s red blood cells, which can then lead to the destruction of the baby’s red blood cells.
How Common Is HDN?
HDN is relatively uncommon, occurring in approximately 1 in 1,000 live births in the United States. It is more common in certain ethnic groups, such as African Americans and Hispanics, and in women of childbearing age who are over 35 years old.
How Is HDN Diagnosed?
HDN is typically diagnosed through a combination of maternal blood tests, fetal ultrasounds, and cord blood tests. If HDN is suspected, the baby will usually be tested within 24 hours of birth.
How Is HDN Treated?
HDN is typically treated with a series of blood transfusions. These transfusions help to replace the baby’s destroyed red blood cells with healthy ones. In some cases, exchange transfusions may be necessary in order to completely replace the baby’s blood. In addition, the baby may be given medication to help prevent further destruction of red blood cells.