Hemolytic anemias are a group of disorders that cause the body to destroy red blood cells more quickly than it can produce them. They can range from mild to severe, and the signs and symptoms can vary depending on the type and severity of the disorder. Knowing how to tell the difference between hemolytic anemias can help you get the right diagnosis and treatment.
Symptoms of Hemolytic Anemias
The most common symptoms of hemolytic anemias include fatigue, shortness of breath, and a pale complexion. Other symptoms may include jaundice, dark urine, headaches, dizziness, chest pain, and an enlarged spleen or liver.
Types of Hemolytic Anemias
The three main types of hemolytic anemias are inherited, acquired, and secondary.
Inherited hemolytic anemias are caused by a genetic abnormality, such as a mutation in a gene that codes for a protein involved in red blood cell production or destruction. Examples of inherited hemolytic anemias include sickle cell anemia, thalassemia, and pyruvate kinase deficiency.
Acquired hemolytic anemias are caused by an outside factor, such as a medication, infection, or exposure to a toxin. Examples of acquired hemolytic anemias include autoimmune hemolytic anemia, drug-induced hemolytic anemia, and paroxysmal nocturnal hemoglobinuria.
Secondary hemolytic anemias are caused by another underlying condition, such as kidney disease or liver disease.
Diagnosis of Hemolytic Anemias
Your doctor will likely do a physical exam and order a complete blood count (CBC) to diagnose hemolytic anemias. The CBC will measure the number of red blood cells in your blood and can help determine if the red blood cells are being destroyed faster than they are being produced.
Your doctor may also order other tests, such as a peripheral blood smear, to look for abnormal cells. They may also order a reticulocyte count to measure the number of immature red blood cells in your blood, which can help determine if your body is responding to the anemia.
Treatment of Hemolytic Anemias
Treatment for hemolytic anemias depends on the type and severity of the disorder. Treatment may include medication, transfusions, and lifestyle changes. In some cases, a bone marrow transplant may be necessary.
If you have been diagnosed with a hemolytic anemia, it is important to follow your doctor's instructions and get regular follow-up care.