The chances of developing Amyotrophic Lateral Sclerosis (ALS) if your father had it depends on the genetic makeup of an individual. While there is no single gene responsible for the disorder, there are some genetic mutations that increase the likelihood of ALS.
Genetic Factors
It is estimated that about 5 to 10 percent of ALS cases are inherited from a parent. This means that if your father had ALS, you are at an increased risk of developing the disorder. However, it is important to note that even if a person has a family history of ALS, it does not guarantee that they will develop the disorder.
Researchers have identified several gene mutations that are associated with increased risk of developing ALS. These include mutations in the SOD1, TARDBP, FUS and C9ORF72 genes. People who have a family history of ALS and who have any of these gene mutations will have a higher risk of developing the disorder.
Environmental Factors
In addition to genetics, certain environmental factors may also increase the risk of developing ALS. Exposure to toxins such as lead and mercury have been linked to an increased risk of ALS. Other environmental factors that may increase the risk of ALS include smoking, lack of exercise, and a diet that is high in saturated fats.
Prevention
There is no sure way to prevent ALS, but there are some steps that can be taken to reduce the risk of developing the disorder:
• Avoid exposure to toxins such as lead and mercury.
• Exercise regularly and maintain a healthy weight.
• Eat a balanced diet that is low in saturated fats.
• Avoid smoking or using other tobacco products.
• Speak to your doctor about your family history of ALS and if you have any genetic mutations that increase your risk of developing the disorder.
It is important to remember that even if you have a family history of ALS, it does not guarantee that you will develop the disorder. However, by taking steps to reduce your risk, you can help reduce your chances of developing the disorder.