Acromegaly is a rare disorder that is caused by an excess of growth hormone (GH) produced by the pituitary gland. This excess of GH causes the body to produce too much insulin-like growth factor (IGF-1). High levels of IGF-1 can lead to physical changes such as an enlarged tongue, jaw, and hands, as well as other medical complications.
What is IGF?
IGF stands for insulin-like growth factor, which is a hormone produced by the body in response to growth hormone (GH). IGF is important for growth and development throughout childhood and into adulthood. It helps regulate body composition, bone density, and muscle mass. In adults, IGF helps maintain overall health.
What Causes High IGF Levels in Acromegaly?
In acromegaly, the pituitary gland produces too much GH. This causes the body to produce excessive amounts of IGF-1. High levels of IGF-1 can lead to physical changes such as an enlarged tongue, jaw, and hands, as well as other medical complications.
How is IGF Treated in Acromegaly?
Treatment of acromegaly depends on the severity of symptoms and the underlying cause. Treatment may include medications to reduce GH levels, surgery to remove the tumor, and radiation therapy. Treatment may also include lifestyle changes such as diet and exercise. These changes can help reduce IGF levels and help control the symptoms of acromegaly.