Polyendocrine syndrome is a medical condition that is characterized by the simultaneous dysfunction of two or more endocrine glands. This condition is also known as polyendocrinopathy syndrome and is usually caused by autoimmune disorders. The symptoms of polyendocrine syndrome vary depending on which endocrine glands are affected. Commonly affected glands are the thyroid, adrenal, pancreas, parathyroid and gonads. The most common symptom of polyendocrine syndrome is fatigue, which is due to the imbalance of hormones in the body. Other symptoms may include weight gain, hair loss, skin changes, joint pain, and digestive problems. Treatment of polyendocrine syndrome is based on the underlying cause, and may include medications, lifestyle changes, and dietary modifications.