Rheumatoid arthritis (RA) is an autoimmune disorder that causes inflammation, pain, and stiffness in the joints. It can also affect other organs and tissues in the body. While the exact cause of RA is not known, there are certain factors that may play a role in its development.
Genetics
RA is more common in people who have a family history of the condition. Approximately 20-25% of people who have RA have a first-degree relative with the condition. People who are of certain ethnicities, such as Caucasian and African-American, are more likely to develop RA than those of other ethnic backgrounds.
Environmental Factors
The environment may also play a role in triggering the onset of RA. Certain environmental triggers, such as smoking, and exposure to certain chemicals, such as silica dust, may increase a person’s risk of developing RA.
Infections
Infections with certain viruses or bacteria may also trigger the development of RA. For example, the Epstein-Barr virus has been linked to an increased risk of RA.
Hormones
Hormones may also play a role in the development of RA. Women are more likely to develop RA than men, and the risk of developing the condition increases with age.
Immune System
A weakened immune system may also increase a person’s risk of developing RA. A person with an autoimmune disorder, such as lupus or psoriasis, is more likely to develop RA.
Stress
Stressful events may also trigger the onset of RA. It is not clear how stress affects the development of RA, but it may trigger the body’s immune system to become overactive and lead to inflammation.
While the exact cause of RA is not known, it is clear that there are certain factors that may play a role in its development. It is important to understand these factors so that steps can be taken to reduce the risk of developing the condition.