There are several medicines available that can help with a sore throat. For mild sore throats, over the counter (OTC) medications such as ibuprofen, acetaminophen, or throat lozenges can be taken to reduce pain and inflammation. For more severe sore throats, you can speak to your doctor or pharmacist about antibiotics, which can help fight infection. Additionally, there are several natural remedies that can be helpful, such as drinking warm tea with honey, gargling with salt water, and using a humidifier to keep your throat moist.