Two-polyglandular autoimmune syndrome (also known as polyglandular autoimmune syndrome type 2, or PAS-2) is an autoimmune condition characterized by the body attacking its own glands. It is a rare disorder which can cause a variety of symptoms, including fatigue, weight loss, and fever, as well as other autoimmune conditions. The condition is typically diagnosed in children, but adults can also be affected.
Symptoms of Two-polyglandular Autoimmune Syndrome
The symptoms of two-polyglandular autoimmune syndrome can vary widely from person to person. Common symptoms may include:
• Fatigue
• Weight loss
• Fever
• Muscle weakness
• Anemia
• Low blood pressure
• Autoimmune conditions such as vitiligo, alopecia, and thyroiditis
• Abnormal blood levels of calcium, magnesium, and other minerals
• Abnormal levels of hormones, such as cortisol
Diagnosis of Two-polyglandular Autoimmune Syndrome
If a person has any of the symptoms listed above, a doctor may order tests to check for two-polyglandular autoimmune syndrome. Diagnosis typically involves blood tests to check for abnormal hormone levels, as well as imaging tests such as X-rays and MRIs to look for any signs of inflammation or damage to the glands.
Treatment of Two-polyglandular Autoimmune Syndrome
The treatment of two-polyglandular autoimmune syndrome depends on the individual's specific symptoms. In general, the goal of treatment is to reduce inflammation and suppress the immune system. Treatment may include medications such as corticosteroids and immunosuppressants, as well as lifestyle changes such as exercise and a healthy diet. In some cases, surgery may be necessary to remove damaged glands.