Ankylosing spondylitis is an inflammatory type of arthritis that primarily affects the spine. It is an autoimmune disorder, meaning that it is caused by the body’s own immune system mistakenly attacking healthy cells and tissues. The exact root cause of ankylosing spondylitis is unknown, however, research suggests that it is caused by a combination of genetic predisposition and environmental factors. Genetic predisposition refers to a person’s unique genetic makeup, which can make them more likely to develop certain diseases, such as ankylosing spondylitis. Environmental factors can include exposure to certain viruses or bacteria, as well as lifestyle factors, such as diet, smoking, and stress levels. While the exact cause of ankylosing spondylitis is unknown, understanding the potential causes may help with developing effective treatments and prevention strategies.