A comprehensive blood test to assess pancreatic function is the Fecal Elastase-1 (FE-1) test. FE-1 is an enzyme produced by the pancreas and it is measured in the stool. It is considered the most reliable test for pancreatic function because it is not affected by other digestive enzymes, is relatively inexpensive, and is not affected by drugs. Additionally, FE-1 is a sensitive marker of pancreatic function, meaning it can detect even small changes in the pancreas. It is also a noninvasive test that does not require a blood sample. Finally, FE-1 has a high degree of accuracy, which makes it the most reliable test for pancreatic function.