The most common presenting symptom in patients with acromegaly is enlargement of the soft tissues and bony structures of the face, hands, and feet. This is caused by enlargement of the bones and soft tissues, such as the skin, due to excessive growth hormone (GH) production.
Patients with acromegaly may also experience symptoms such as fatigue, weakness, joint pain, headaches, excessive sweating, and excessive hair growth. In addition, patients may experience vision changes or changes in their oral cavity, such as an enlarged tongue, thickening of the skin on the palms of the hands and the soles of the feet, and enlargement of the nose, lips, and ears.
Other symptoms of acromegaly may include changes in the shape of the skull, increased size of the jaw, and enlargement of the sinuses. In addition, patients may experience an increase in their blood pressure, diabetes mellitus, and a decrease in their fertility.
It is important to note that these symptoms can vary from person to person and can be more or less pronounced depending on the severity of the acromegaly. Early diagnosis and treatment of acromegaly is important to reduce the risk of complications.