The most common early symptom of aplastic anemia is fatigue. People with aplastic anemia often experience an overwhelming feeling of exhaustion that does not improve with rest. Other symptoms can include easy bruising and bleeding, paleness, shortness of breath, a rapid heart rate, and frequent infections. Other signs and symptoms of aplastic anemia may include enlarged lymph nodes, a sore throat, fever, an enlarged spleen, and jaundice. Some people may also experience dizziness, headaches, chest pain, and anemia-related symptoms such as lightheadedness, pallor, and difficulty concentrating. If you are experiencing any of these symptoms, it is important to seek medical attention right away. Aplastic anemia can be treated with medications, blood transfusions, and bone marrow transplants.