The most common clinical manifestation of chronic pancreatitis is abdominal pain. This pain usually begins as a dull ache in the upper abdomen and can become more severe over time. Other symptoms may include weight loss, jaundice, nausea, vomiting, and diarrhea. In some cases, chronic pancreatitis can lead to malabsorption, diabetes, and pancreatic insufficiency. Treatment typically includes pain management and dietary modifications. Surgery may also be necessary to remove damaged tissue and restore normal pancreatic function.