Chronic pancreatitis is a long-term inflammation of the pancreas that leads to permanent damage and destruction of the organ. The main clinical syndrome of chronic pancreatitis is abdominal pain in the upper abdomen, often radiating to the back. Other symptoms may include nausea, vomiting, weight loss, malabsorption, and diabetes. Abdominal pain is usually worse after eating, and it can be accompanied by fever, chills, and night sweats. Treatment of chronic pancreatitis involves controlling pain, preventing complications, and managing nutritional deficiencies.