The first line of treatment for aspergillosis typically involves antifungal medications. This is because the primary cause of aspergillosis is an allergic reaction to the fungi Aspergillus, which can be treated with antifungal drugs. In some cases, if the infection is severe or life-threatening, corticosteroids may also be prescribed to reduce inflammation. In addition, immunosuppressant medications may be prescribed to reduce the body’s immune response to the fungi. Finally, when possible, surgery may be an option to remove the fungal tissue from the affected area.