Adie Syndrome is a rare neurological disorder characterized by an abnormally slow pupil reaction to light, reduced deep tendon reflexes, and loss of the ability to sweat on the affected side. It is also known as Adie's Tonic Pupil, Adie's Syndrome, Adie's Syndrome Tonic Pupil, and Holmes-Adie Syndrome.
Symptoms of Adie Syndrome
The main symptom of Adie Syndrome is an abnormally slow pupil reaction to a bright light. These pupils may also become larger than usual (dilated) and may not constrict in the dark. Other symptoms of Adie Syndrome include reduced deep tendon reflexes (such as ankle reflexes), decreased or absent sweating on the affected side, and decreased sensitivity to touch or pain on the affected side.
Causes of Adie Syndrome
The exact cause of Adie Syndrome is unknown. It is believed to be caused by damage to the postganglionic parasympathetic fibers of the oculomotor nerve. This nerve is responsible for pupil constriction and other autonomic functions. The damage is thought to be caused by an inflammation or viral infection, but this has not been proven.
Diagnosis of Adie Syndrome
Adie Syndrome can be diagnosed by a physical examination. A doctor will look for an abnormally slow pupil reaction to light, reduced deep tendon reflexes, and decreased or absent sweating on the affected side. Other tests such as electrodiagnostic testing and imaging may be done to rule out other causes of the symptoms.
Treatment of Adie Syndrome
Adie Syndrome is a chronic condition, so treatment is aimed at managing the symptoms. Medications such as pilocarpine may be used to help constrict the pupil. Other treatments may include physical therapy and lifestyle modifications to help with the decreased reflexes and sweating.