First line drug therapy for dermatitis and eczema typically includes topical corticosteroids, topical calcineurin inhibitors, and topical antiseptics. Topical corticosteroids are the most commonly prescribed treatment for mild to moderate dermatitis and eczema. These drugs reduce inflammation, redness, and itching associated with the condition. They come in lotions, creams, ointments, and sprays, and should be applied to the affected area twice a day. Topical calcineurin inhibitors, such as tacrolimus and pimecrolimus, are alternatives to corticosteroids that can be used to treat mild to moderate dermatitis and eczema. These drugs work by suppressing the immune system and reducing inflammation. They are generally considered to be safer than topical corticosteroids and are available as creams or ointments. Topical antiseptics, such as benzoyl peroxide and chlorhexidine, can also be used to treat dermatitis and eczema. These drugs are used to reduce the bacteria on the skin that can cause infection. They come in washes and creams, and should be applied to the affected area twice a day. In severe cases of dermatitis and eczema, systemic medications, such as oral corticosteroids, may be prescribed. These drugs work by suppressing the immune system and reducing inflammation throughout the body.