Adie syndrome, or tonic pupil, is a rare neurological disorder that affects the function of the pupil of the eye. It is characterized by an abnormally slow reaction of the pupil to light and accommodation, and a decreased response to near effort. It is caused by damage to the postganglionic parasympathetic fibers that innervate the iris of the eye. The condition is named after William John Adie, a British neurologist who first described it in 1927.
Symptoms:
The most common symptom of Adie syndrome is a tonic pupil, which is an abnormally slow reaction of the pupil to light and accommodation. The pupil may appear dilated and the patient may be unable to adjust the size of the pupil in response to light and accommodation. In addition, the patient may also have a decreased response to near effort. Other symptoms may include decreased or absent deep tendon reflexes, dry mouth, and decreased sweating.
Diagnosis:
Adie syndrome is typically diagnosed by an eye examination. The physician will look for a tonic pupil and decreased or absent deep tendon reflexes. The pupil size can be tested using a light source and the patient will be asked to focus on a near object. An electroretinogram may also be performed to assess the function of the optic nerve.
Treatment:
There is no specific treatment for Adie syndrome, but some symptoms can be managed. Artificial tears may be used to help relieve dry eye symptoms. Glasses may be prescribed to help the patient focus at near distances. In some cases, surgical intervention may be necessary to correct the pupil size.