Germ cell tumors (GCTs) are a type of cancer that starts in the cells that produce eggs (ova) or sperm (spermatozoa). They are most commonly found in the gonads (ovaries or testes), but can also occur in other parts of the body, such as the abdomen, chest, or brain. GCTs are the most common type of cancer in adolescents and young adults.
Types of Germ Cell Tumors
GCTs can be divided into two main types: germ cell tumors of the gonads (ovarian GCTs or testicular GCTs) and extragonadal germ cell tumors (EGCTs).
Germ cell tumors of the gonads are further divided into two subtypes: seminomas and non-seminomas. Seminomas are usually found in men, while non-seminomas are usually found in women. Non-seminomas can also be found in men, but less often.
Extragonadal germ cell tumors (EGCTs) are tumors that originate outside of the gonads. They are usually found in the abdomen, chest, or brain. EGCTs are divided into three subtypes: embryonal, endodermal sinus, and choriocarcinoma.
Diagnosis of Germ Cell Tumors
GCTs are usually diagnosed with imaging tests, such as ultrasound, CT scan, or MRI. A biopsy may also be done to confirm the diagnosis.
Treatment of Germ Cell Tumors
Treatment of GCTs depends on the type and location of the tumor, as well as the age and health of the patient. Treatment options include surgery, radiation therapy, chemotherapy, and targeted therapy.
GCTs can be treated successfully with the right combination of treatments. Most people with GCTs have a good chance of a cure.