AST (Aspartate Transaminase) and ALT (Alanine Transaminase) are two enzymes found in the liver. An increase in these enzymes may indicate damage or inflammation to the liver.
Causes of an Increase in AST and ALT
There are numerous potential causes of an increase in AST and ALT. Some of the most common causes include:
Infection: Viral hepatitis, such as hepatitis A, B, and C, can cause a spike in AST and ALT. Other infections that can lead to an increase in AST and ALT levels include mononucleosis and cytomegalovirus.
Liver Disease: Diseases of the liver, such as cirrhosis, can cause an increase in AST and ALT.
Alcohol Abuse: Excessive alcohol consumption can lead to an increase in AST and ALT.
Drugs: Certain medications, such as statins, can lead to an increase in AST and ALT.
Other Causes: Other causes of an increase in AST and ALT include cardiac arrest, shock, or trauma.
Diagnosis and Treatment
If you experience a sudden increase in AST and ALT, your doctor may order a series of tests to diagnose the cause. These tests may include a physical exam, blood tests, imaging tests, and a liver biopsy. Once a diagnosis is made, your doctor can develop a treatment plan. Treatment for an increase in AST and ALT may include medications, lifestyle changes, and surgery, depending on the underlying cause.