Polyglandular disease (PGD) is a rare disorder where the body's immune system attacks its own glands, leading to a variety of symptoms. Symptoms of PGD can vary depending on the type of PGD, but common signs and symptoms include fatigue, weight loss or gain, fever, joint pain, abdominal pain, skin changes, anemia, and low blood sugar.
The most common type of PGD is type 1, also known as autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). The most common symptoms of APECED include fatigue, weight loss, insulin-dependent diabetes, hypoparathyroidism, Addison’s disease, and candidiasis. People with APECED may also experience alopecia, vitiligo, premature graying of the hair, and nail dystrophy.
Type 2 PGD, also known as Schmidt’s syndrome, is characterized by the presence of two or more autoimmune disorders. Common symptoms include hypothyroidism, type 1 diabetes, vitiligo, alopecia, and adrenal insufficiency.
Type 3 PGD is less common and is characterized by the presence of autoimmune thyroid disease and Addison’s disease. Symptoms of type 3 PGD include fatigue, weight loss, low blood pressure, low blood sugar, and skin changes.
In rare cases, people with PGD can also experience other symptoms, such as joint pain, infertility, and anemia. It is important to note that symptoms of PGD can vary from person to person and can be mild to severe. Therefore, it is important to talk to a doctor if you experience any of the above symptoms or if you have any concerns.