Chronic Pancreatitis is a condition in which the pancreas becomes inflamed and scarred over time, leading to a decrease in its ability to produce enzymes and hormones. This can cause a number of digestive and metabolic problems. The pathological changes that occur in chronic pancreatitis include:
Stricture Formation
The most common pathological change in chronic pancreatitis is the formation of strictures, which are areas of narrowing or scarring in the pancreatic ducts. This can cause a blockage of digestive enzymes, leading to malabsorption of nutrients, as well as an accumulation of toxins in the pancreas.
Pancreatic Fibrosis
Another common pathological change in chronic pancreatitis is the development of pancreatic fibrosis. This is the formation of excess collagen and other connective tissues in the pancreas, which can reduce its ability to produce hormones and enzymes.
Destruction of Islet Cells
The destruction of islet cells is another common pathological change in chronic pancreatitis. Islet cells are responsible for producing insulin and other hormones, so the destruction of these cells can lead to an increased risk of diabetes.
Inflammation of the Pancreas
Inflammation of the pancreatic tissue is another common pathological change in chronic pancreatitis. This can cause pain and discomfort in the abdomen, as well as an increased risk of infection.
Gastric Acid Secretion
Gastric acid secretion is another common pathological change in chronic pancreatitis. This can lead to an increased risk of gastric ulcers and other digestive issues.
