Cholangiocarcinoma is an aggressive form of cancer that affects the bile ducts, and its end-stage symptoms are highly variable depending on the individual. Common symptoms of advanced cholangiocarcinoma include jaundice, abdominal pain, nausea, fever, and weight loss. Other symptoms may include anorexia, fatigue, itching, and a lump in the abdomen. In some cases, the cancer may spread to the lungs, resulting in difficulty breathing, coughing, and chest pain. As the cancer progresses, mental confusion, seizures, and difficulty with swallowing can occur. Patients may also experience pain, numbness, and tingling in their extremities. Ultimately, cholangiocarcinoma can lead to organ failure, coma, and death. It is important to seek medical attention as soon as any of these symptoms appear, as early diagnosis and treatment can improve outcomes.