Subtitle: Early Mediators of Allergic Rhinitis
Allergic rhinitis is a common inflammatory condition of the nasal airways, which can cause significant discomfort and disruption to daily life. It is triggered by environmental allergens, such as pollen and dust, and results in a range of symptoms, including sneezing, nasal congestion, runny nose, and itchy eyes.
The early mediators of allergic rhinitis are substances released by the body in response to the allergen. These mediators include histamine, prostaglandins, leukotrienes, cytokines, and chemokines. Histamine is the most well-known mediator and is responsible for many of the symptoms of allergic rhinitis, including sneezing and itching. Prostaglandins cause the nasal mucosa to swell and can lead to increased mucus production. Leukotrienes cause bronchoconstriction and increased mucus production, which can lead to wheezing. Cytokines and chemokines play a role in the recruitment and activation of inflammatory cells.
In order to reduce the symptoms of allergic rhinitis, it is important to identify and avoid the allergen that is causing the reaction. Medications such as antihistamines, corticosteroids, and leukotriene receptor antagonists can also be used to reduce the severity of symptoms. Allergy immunotherapy is also an option for long-term control of symptoms.
