The 7 risk factors for coronary artery disease are smoking, high cholesterol, high blood pressure, diabetes, obesity, physical inactivity, and familial history. Smoking increases the risk of developing coronary artery disease by reducing circulation in the arteries. High cholesterol can build up in the arteries and lead to blockages. High blood pressure can damage the walls of the arteries, causing them to narrow. Diabetes can damage the walls of the arteries and lead to blockages. Obesity increases the risk of developing high cholesterol, high blood pressure, and diabetes, all of which can lead to coronary artery disease. Physical activity is important for keeping your heart healthy and reducing your risk of coronary artery disease. Lastly, family history of coronary artery disease increases the risk of developing the condition.