Bacteria are classified into two primary types: Gram-positive and Gram-negative. Gram-positive bacteria have a thick cell wall that is composed of peptidoglycan and teichoic acid, which gives them a positive charge when stained with the Gram stain. This causes them to retain the crystal violet dye used in the Gram stain, and appear purple under a microscope. Examples of Gram-positive bacteria include Streptococcus, Staphylococcus, Bacillus, Clostridium, and Corynebacterium.
Gram-negative bacteria, on the other hand, have a thin peptidoglycan layer sandwiched between two layers of phospholipids, which gives them a negative charge when stained with the Gram stain. This results in them losing the crystal violet dye and appearing pink or red under a microscope. Examples of Gram-negative bacteria include Escherichia coli, Salmonella, Pseudomonas, Neisseria, and Helicobacter.
Gram-positive and Gram-negative bacteria differ in their cell wall composition, shape, and response to antibiotics. Gram-positive bacteria are more susceptible to antibiotics such as penicillin and vancomycin, while Gram-negative bacteria are often resistant to these antibiotics. Gram-positive bacteria are typically round or oval-shaped, while Gram-negative bacteria are usually rod-shaped.