People with AIS, or androgen insensitivity syndrome, are resistant to the effects of androgens, which are hormones that are important for the development of male characteristics. This resistance is due to a genetic abnormality that results in the body not responding to androgens as it should. As a result, people with AIS typically have female external genitalia, despite having XY chromosomes.
When it comes to the effects of androgens, people with AIS are resistant to the effects of testosterone, which is the primary androgen in males. This means that people with AIS may have female secondary sex characteristics, such as breasts, and may not have the same levels of muscle mass and body hair as males. In addition, people with AIS may have difficulty in producing sperm and may have an inability to produce testosterone.
People with AIS are also resistant to the effects of dihydrotestosterone (DHT). DHT is an androgen that is important for the development of male characteristics such as facial hair and body hair. People with AIS may have reduced facial and body hair, and may not develop male-pattern baldness.
The resistance to androgens can also affect the development of the reproductive organs. People with AIS may have an underdeveloped uterus, and they may have an inability to produce eggs. In addition, people with AIS may have an underdeveloped prostate gland, which can lead to issues with bladder control and difficulty in urinating.
Overall, people with AIS are resistant to the effects of androgens, which can have a number of effects on their physical and reproductive health. AIS is a genetic disorder, and it is important to seek medical care if you think you or someone you know may have AIS.
