Acromegaly is a condition caused by an excess of growth hormone (GH) and, as a result, an overproduction of insulin-like growth factor 1 (IGF-1). High levels of IGF-1 are characteristic of acromegaly, resulting in a variety of physical changes.
IGF-1 is typically elevated in acromegaly due to the overproduction of GH from the pituitary gland. Increased GH levels stimulate the liver to produce more IGF-1 than normal. These higher levels of IGF-1 cause an enlargement of organs and body parts, including the hands, feet, and face.
In addition to the physical features, acromegaly can lead to severe health problems, such as diabetes, heart disease, and hypertension. Elevated IGF-1 levels can also increase the risk of certain cancers.
The diagnosis of acromegaly is based on elevated levels of IGF-1 in the blood. Treatment of acromegaly depends upon the cause and may include medications, surgery, or radiation therapy. The goal of treatment is to reduce GH and IGF-1 levels to normal.
In conclusion, IGF-1 is typically high in acromegaly due to increased levels of GH from the pituitary gland. Treatment of acromegaly focuses on reducing GH and IGF-1 levels to normal.