Holmes-Adie Syndrome is an uncommon neurological disorder, affecting fewer than one person in every 100,000. It is usually diagnosed in adults, most commonly between the ages of 20 and 40. The syndrome is named after Sir William Gowers and E. Adie, two physicians who first described the condition in the early 1900s.
Signs and Symptoms of Holmes-Adie Syndrome
The most common symptom of Holmes-Adie Syndrome is a decreased sensitivity to light touch or vibration, known as hyporeflexia. Other symptoms may include pupil abnormalities, such as dilated pupils that are slow to react to light, and reduced sweating (anhidrosis). Patients may also experience difficulty with urination, constipation, and dry eyes.
Causes of Holmes-Adie Syndrome
The exact cause of Holmes-Adie Syndrome is unknown, but it is thought to be caused by damage to the autonomic nervous system, which controls involuntary body functions. This damage can be caused by a virus or other infection, a head injury, or a tumor.
Diagnosis of Holmes-Adie Syndrome
Holmes-Adie Syndrome is usually diagnosed based on a medical history and physical examination. The doctor may also request additional tests, such as a visual field test, to help confirm the diagnosis.
Treatment of Holmes-Adie Syndrome
There is no cure for Holmes-Adie Syndrome, but the symptoms can often be managed with lifestyle modifications and medications. For example, artificial tears may be used to treat dry eyes, and medications may be prescribed to help control bladder and bowel symptoms. Physical therapy and occupational therapy may also be recommended to help maintain muscle strength and coordination.