Query:
How rare is ALS before 40?
Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease, is an incredibly rare neurodegenerative disorder that affects neurons in the brain and spinal cord, leading to progressive muscle weakness and eventual paralysis. It is a terminal illness, and it is estimated that two out of every 100,000 people are afflicted with it in the United States alone.
Although the average age of onset is between 55 and 65, cases of ALS before the age of 40 have been reported. In fact, according to research conducted by the International Alliance of ALS/MND Associations, 4.4% of ALS cases occur in people under 40. As for the numbers of these cases, one study found that approximately 1,000 people under the age of 40 were diagnosed with ALS between 1999 and 2014.
It is important to note that although ALS is rare before the age of 40, it is also important to be aware that it can happen. It is important to know the signs and symptoms of ALS to catch it as early as possible. These include muscle weakness, twitching, cramping and stiffness in the limbs, difficulty swallowing, and slurred speech.
It is also important to know that although the cause of ALS is unknown, some risk factors have been identified. These include age, gender, family history, and certain genetic mutations. For example, the most common genetic mutation associated with ALS is a mutation in the C9orf72 gene, which is found in about 10-15% of all ALS cases.
In conclusion, although ALS before the age of 40 is incredibly rare, it is still important to be aware of the signs and symptoms, and to know the risk factors associated with the disease. Early diagnosis is key to providing the best treatment and care for those affected.