Polyglandular autoimmune syndrome type 2 (PAS2) is an autoimmune disorder in which the body's immune system attacks its own organs and tissues. Treatment of PAS2 depends on the individual patient and the organs affected. The main goal of treatment is to reduce inflammation, decrease symptoms, and improve quality of life.
The first line of treatment for PAS2 is typically immunosuppressant medications. These medications are designed to reduce the activity of the immune system, thereby reducing inflammation and symptoms. Common immunosuppressants used to treat PAS2 include glucocorticoids, azathioprine, cyclophosphamide, and methotrexate. In severe cases, the patient may require intravenous or oral steroids.
In some cases, immunomodulatory medications may also be used. These medications work by targeting specific pathways in the immune system, thus altering its response. Common immunomodulatory medications used to treat PAS2 include mycophenolate mofetil and tacrolimus.
In addition to medications, lifestyle changes can also help reduce symptoms of PAS2. It is important to maintain an active lifestyle, get regular exercise, and manage stress. Eating a healthy diet and avoiding environmental triggers such as cigarette smoke and air pollutants can also be beneficial.
Finally, it is important to get regular check-ups with your doctor. Early diagnosis and treatment of PAS2 can help reduce the risk of long-term complications. It is also important to monitor for signs of infection, as immunosuppressant medications can increase the risk of infection.