Lupus is a chronic autoimmune disease that causes inflammation, pain, and tissue damage throughout the body. Its symptoms can be similar to those of other diseases, making it difficult to diagnose. Several tests and procedures are used to diagnose lupus and confirm a diagnosis.
The first step in diagnosing lupus is to perform a physical examination and review of the patient's medical history. The doctor will look for signs and symptoms that are associated with lupus, such as joint pain, skin rashes, fatigue, and fever. They may also order blood tests such as a complete blood count (CBC), erythrocyte sedimentation rate (ESR), and antinuclear antibody (ANA) test.
The CBC is a test that measures levels of red and white blood cells and platelets in the bloodstream. Abnormal levels can indicate an infection or inflammation in the body. The ESR measures the rate at which red blood cells settle to the bottom of a test tube. An elevated ESR can be a sign of inflammation in the body.
The ANA test detects antibodies that are produced in response to the body's own cells. A positive result on the ANA test may indicate the presence of lupus, but it is not definitive and other tests will need to be conducted to confirm the diagnosis.
Additional tests may also be used to determine the presence of lupus. These may include a kidney biopsy, blood tests to measure levels of complement proteins, urine tests to detect protein or blood, and X-rays or ultrasounds of the joints or organs.
If the tests and physical examination indicate lupus, a doctor will consult with a rheumatologist, a doctor who specializes in the diagnosis and treatment of autoimmune diseases. The rheumatologist will review all of the patient's test results and make a diagnosis based on the criteria established by the American College of Rheumatology.
Once lupus is diagnosed, the doctor will work with the patient to develop a treatment plan. Treatment plans may include medications, lifestyle changes, and physical therapy. The goal of treatment is to reduce the symptoms of lupus and prevent flare-ups.