Autoimmune hemolytic anemia (AIHA) is an autoimmune disorder in which the body's own immune system mistakenly attacks and destroys its own red blood cells. AIHA can be caused by a variety of underlying conditions, including infections, genetic disorders, and autoimmune disorders such as lupus and rheumatoid arthritis.
What Causes AIHA?
AIHA can be caused by several underlying conditions, including infections, genetic disorders, and autoimmune disorders. Infections such as Epstein-Barr virus, cytomegalovirus, and hepatitis C can trigger AIHA. In some cases, the cause of AIHA is unknown.
Genetic Causes of AIHA
AIHA can be caused by certain genetic disorders, such as sickle cell anemia, thalassemia, and spherocytosis. These disorders interfere with the production of healthy red blood cells, leading to anemia.
Autoimmune Causes of AIHA
AIHA can also be caused by an autoimmune disorder, which occurs when the body's own immune system mistakenly attacks and destroys its own red blood cells. Autoimmune disorders such as lupus and rheumatoid arthritis can cause AIHA.
Diagnosing AIHA
AIHA is typically diagnosed through a physical exam, blood tests, and other tests such as a complete blood count and reticulocyte count. In some cases, a bone marrow biopsy may be needed to confirm the diagnosis.
Treating AIHA
Treatment for AIHA depends on the underlying cause. In some cases, treatment may include medications to suppress the immune system or to increase red blood cell production. In other cases, a blood transfusion may be necessary.