Yes, Stage 1 kidney disease does have symptoms. These can include fatigue, decreased appetite, nausea, and swelling of the ankles, feet, and hands. In some cases, patients may have an increased need to urinate, especially at night. In addition, they may experience difficulty concentrating, difficulty sleeping, and muscle cramps. If the disease is left untreated, it can also lead to high blood pressure, anemia, bone disease, and even cardiovascular disease. It's important to note that the severity of symptoms can vary depending on the individual, so it's important to seek medical advice if you suspect you may have kidney disease.