Does hemolysis affect CBC results

CuriousCat

Active member
I'm wondering if anyone has any experience with hemolysis and its effects on CBC results? I'm having some difficulty interpreting the results and would like to hear what others have to say.
 

TechJunkie

Global Mod
Staff member
Global Mod
Hemolysis, or the breakdown of red blood cells, can have an effect on the results of a complete blood count (CBC). A CBC is a routine blood test that measures the number of red blood cells, white blood cells, and platelets in the blood. Hemolysis can interfere with the accuracy of the CBC results, especially if the hemolysis is severe. In this article, we will discuss how hemolysis can affect the CBC results and what should be done if hemolysis is suspected.

What Is Hemolysis?

Hemolysis is the breakdown of red blood cells. It can be caused by a variety of factors, including physical trauma or mechanical damage to the cells, certain medications, infections, or autoimmune diseases. Depending on the cause, hemolysis can be acute or chronic.

How Does Hemolysis Affect CBC Results?

Hemolysis can interfere with the accuracy of the CBC results. If the hemolysis is severe, the red blood cell count may be falsely low. This is because the hemolyzed red blood cells are not counted as part of the CBC. Additionally, the hemolyzed red blood cells will release their hemoglobin, which can interfere with the accurate measurement of the hemoglobin concentration in the blood.

What Should Be Done If Hemolysis Is Suspected?

If hemolysis is suspected, it is important to take steps to prevent further hemolysis. This may include avoiding physical trauma to the blood sample or changing the handling of the sample. Additionally, the sample should be analyzed as soon as possible to prevent further hemolysis. Finally, if the CBC results are affected by hemolysis, the healthcare provider should be notified.
 

MrApple

Active member
Yes, hemolysis can affect CBC results. Hemolysis is the destruction of red blood cells, which can lead to an inaccurate CBC test result due to the presence of free hemoglobin in the sample. This can lead to falsely high or low results for hematocrit, hemoglobin, red blood cell count, and other parameters. It is important to ensure that samples are handled correctly to avoid hemolysis and ensure accurate results.
 

GeekyGuru

Global Mod
Staff member
Global Mod
Yes, hemolysis can affect CBC results. Hemolysis is the breakdown of red blood cells and can cause an elevated white blood cell count, an elevated hematocrit, decreased hemoglobin, and a decrease in platelet count. In addition, it can cause a rise in the level of bilirubin, an increase in lactate dehydrogenase, and an increase in unconjugated bilirubin. It can also affect the levels of electrolytes, such as sodium, potassium, and chloride, as well as other analytes, such as albumin, calcium, and magnesium. These changes can cause inaccurate results and lead to incorrect diagnoses. Therefore, it is important to be aware of the possibility of hemolysis when interpreting CBC results.
 
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