Does Angelman Syndrome Become More Severe With Age?
Angelman syndrome is a rare genetic disorder that affects the nervous system. It is characterized by severe intellectual disability, impaired speech, ataxia, and seizures. It is estimated to affect 1 in 12,000 to 20,000 people worldwide. The condition is often diagnosed shortly after birth and is usually diagnosed by age five.
The exact cause of Angelman syndrome is unknown, but it is believed to be caused by a mutation in the UBE3A gene. This mutation is typically inherited from the mother, but in some cases, it can occur spontaneously. Symptoms can vary in severity, but typically include developmental delays, intellectual disability, speech impairment, ataxia, and seizures.
The severity of Angelman syndrome generally does not change as one gets older. However, the symptoms may progress as the person ages. For example, seizures may become more difficult to control, speech and language development may slow down, and mobility may decrease. Additionally, people with Angelman syndrome may experience behavioral problems such as hyperactivity, anxiety, and sleep disturbances.
There is currently no cure for Angelman syndrome, but early intervention can help improve the quality of life for individuals with this condition. Treatments may include physical, occupational, and speech therapies, as well as medications to help control seizures. Behavioral therapies may also be used to help reduce challenging behaviors and improve communication.
In most cases, people with Angelman syndrome can live long and healthy lives with the help of supportive care. With access to appropriate medical care and interventions, individuals with Angelman syndrome can live meaningful, productive lives.