Yes, people with androgen insensitivity syndrome (AIS) are generally infertile. AIS is a genetic disorder caused by an X-linked recessive mutation in the androgen receptor gene on the X chromosome. This disorder results in the body’s inability to respond to androgens (male hormones), leading to a variety of physical and psychological effects.
People with AIS typically have a female-appearing body due to the lack of androgen-mediated masculinization during fetal development, and may be born with ambiguous genitalia. In many cases, this is then further diagnosed through blood tests and genetic analysis.
In terms of fertility, those with AIS are typically infertile as a result of the lack of androgen-dependent development of the male reproductive system. Without adequate androgen signaling, the body does not develop the necessary reproductive organs and hormones to enable conception. Furthermore, the uterus and fallopian tubes may not develop fully, and this can also lead to infertility.
In some cases, it may be possible for those with AIS to become pregnant through assisted reproductive technologies such as in vitro fertilization, but this is not always successful. It is important to note that those with AIS should consult with a fertility specialist to discuss their options.